Effect of Spirulina (Arthrospira platensis) on blood uric acid, hemoglobin and kidney histo-texture of mice treated with acetaminophen

Abstract

Background: Acetaminophenis a medication used to treat pain and fever.It is typically used for mild to moderate pain relief. Spirulina is a biomass of cyanobacteriathat cultivated worldwide and used as a dietary supplement or whole food. It is also used as a feed supplement in the aquaculture, aquarium, and poultry industries. The presentstudy was undertaken todetermine the effect of Spirulinaon blood and kidney in mice.

Methods: Twenty Swiss Albino mice (Mus musculus) were randomly divided into 4 equal groups’ viz., A, B, C, and D. Group A was kept as control and fed only normal diet. Group B was supplemented with acetaminophen where as group C was supplemented with acetaminophen and Spirulina, and group D was treated with Spirulina.

Results: The application of acetaminophen did not have significant effect on hemoglobin and uric acid content. But the addition of Spirulinato the diet increased significantly (P<0.05) hemoglobin and uric acid level. Histopathological examination revealed that no significant changes were found in the kidney of all of treated groups in comparison with the mice of control group.

Conclusions: The research work suggests that long-term ingestion of acetaminophen does not exert a significant change in hemoglobin or uric acid level but spirulina supplemented diet may be associated with the rise in hemoglobin and uric acid level without affecting renal tissue texture in a significant manner.

DOI: https://doi.org/10.33109/bjvmjj19lam1